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Jack Nicholson becomes a werewolf in this bizarre comedy-horror film directed by Mike Nichols. Nicholson plays Will Randall, a book editor with a testosterone deficit who has just been sacked at his publishing firm by a new boss, Raymond Alden (Christopher Plummer). A colleague, Stewart Swinton (James Spader), whom Randall thought was his friend, betrays him. Randall’s personality changes after he hits a wolf with his car and gets bitten by the creature. He immediately feels more powerful, has heightened hearing and vision, and sets about to right the wrongs in his life. He visits Alden at the publisher’s mansion to protest his dismissal, and he is asked to leave — but Alden’s daughter Laura (Michelle Pfeiffer) asks him to stay for lunch. Laura loves to defy her father. Will tells her about the wolf bite, and she becomes attracted to him. But because werewolves usually kill the ones they love, Laura is in danger. Will reasserts his place in the publishing world, supported by his loyal secretary Mary (Eileen Atkins), and his relationship with Laura deepens.
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